Update on Genetics Research in Stuttering

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Re: Chromosome 12 in general stuttering population

From: Dennis Drayna
Date: 17 Oct 2011
Time: 16:55:38 -0500
Remote Name: 165.112.47.66

Comments

The situation you describe in your family is commonly seen. While stuttering clearly clusters in families, all attempts to identify a particular mode of inheritance (dominant, recessive, or X-linked) have been unsuccessful. Even in highly inbred Pakistani families in which we found the first stuttering gene, the mutant version of this gene did not track stuttering perfectly. For example there were two individuals who carried this gene and did not stutter. Both were female, and we think it's possible that they may have stuttered as children, however they do not now. The connection between any gene and stuttering is still absolute, but the mutations we've found to date clearly have a very strong effect in the modest number of people who carry them.


Last changed: 10/17/11